Losartan: An Anti-hypertensive Medicine

About Losartan: Losartan is an antagonist of receptors for angiotensin II. These receptors are present in many regions of the body. Losartan antagonizes the action of angiotensin at all these sites. Often, Losartan is used with other drugs in the management of hypertension, myocardial infarction and cardiac failure. This is the only class of drugs which have been found to prevent hypertrophy and remodelling of the damaged cardiac muscle after a myocardial infarction. Losartan has also been found to decrease the risk of stroke in those patients with hypertension related left-ventricular hypertrophy.

How Losartan Works: Angiotensin is a hormone that has various actions in the body, including increasing blood pressure and inducing the release of renin from the kidney. This in turn releases aldosterone which has a sodium preserving effect on the kidney, eventually leading to a rise in blood pressure. Losartan prevents the action of angiotensin - II on its receptors, and is a competitive antagonist as well as an inverse agonist at these receptors. Thus it blocks vasoconstriction, sympathetic over activity, release of aldosterone and salt re-absorption in the kidney. All these effects culminate in the decreasing of blood pressure in hypertensive patients.
Losartan has very high affinity for the AT1 type of angiotensin - II receptor as compared to the AT2 type. This makes it quite selective for the AT1 type of receptor.

How To Take Losartan: Losartan is usually used as a second line drug in the treatment of hypertension. It also decreases the risk of cerebrovascular attacks in patients with hypertrophy of the left ventricle. Losartan is also used in the management of diabetic nephropathy in patients with type II diabetes mellitus. It reduces proteinuria and slows the progression of nephropathy in diabetic patients. Often, two or three drug regimens including Losartan are used for controlling hypertension and maintaining blood pressure at an optimal level. Hydrochlorothiazide is commonly used in combination with Losartan.
When Losartan Without Prescription is used after a patient has suffered a myocardial infarction, it helps not only in the control of high blood pressure, but also inhibits remodelling of the infracted region of cardiac muscle. This decreases the chances of developing cardiac failure.
Losartan is available as oral tablets in the strengths of 25 mg, 50 mg and 100 mg. The usual recommended starting dose for Losartan is 50 mg once daily as a single dose. Preferably the dose is to taken in the morning and timing of taking the medicine has no relation to meals. In patients taking other drugs along with Buy Losartan No Prescription, usually 25 mg is used, especially in those patients on diuretics. The blood pressure has to be monitored when the patient is started on Losartan No Prescription. If the expected result is not achieved, then twice a day dosage with a maximum dose of 100 mg/day may be permitted with gradual weekly increments in dose.
In patients of diabetic nephropathy, the recommended starting dose of Buy Losartan is 50 mg/ day which is gradually raised to 100 mg/day.

Precautions And Interactions: Losartan is to be used cautiously in the presence of liver dysfunction. Dose should be limited to 50 mg/day in this circumstance. Other conditions where Losartan No Prescription should be used with caution or replaced with another anti-hypertensive agent are in patients with severe congestive cardiac failure, mitral stenosis, aortic stenosis, elderly patients or those who have had an allergic reaction to prior use of an ACE-inhibitor drug. Buy Losartan is not to be used in patients with bilateral renal artery stenosis (narrowing).

Side Effects Of Losartan: More commonly side effects seen with Losartan Without Prescription are hypotension (low blood pressure), dizziness, fatigue, rashes, pain in the joints and occasionally feeling of imbalance. Serious side effects of Buy Losartan Without Prescription can be high blood levels of potassium (hyperkalemia), anaemia, thrombocytopenia, hepatitis, liver dysfunction and allergic symptoms like angioedema.